World number two Jordan Spieth, who captured his third career major at last month's British Open, shared 44th on 145, 11 strokes off the pace, and figures his chances to become the youngest to complete a career Grand Slam this week are over.
However, changes to several holes and the installation of bermuda rough and greens had not suited the four-time major victor, who struggled to consecutive rounds of 72 to lie 10 shots off the lead at halfway.
Kisner was cruising around the course comfortably through the first 15 holes, but a hook into the water on the par-four 16th led to a double bogey.
The idea is I have to get rid of negativity and also not be over enthusiastic in cases like back-to-back birdies or similar.
"The pins were in such tough locations, it was hard to get the ball to feed to the hole", Spieth said after his round.
"Didn't do anything great today but I didn't do anything bad".
"Like Michael (Greller, his caddie) was saying, we could break the season into quarters". But the last two weeks his putting has looked stronger with only 54 total putts thus far in the PGA Championship. He had seven bogeys and a double-bogey, and just one birdie. That's what I'm looking to do here. Those trios will take to Quail Hollow at 10:00 a.m. ET and then the fourth major golf tournament should be in good shape. "Just said, 'OK, I'll bounce it up the cart path and see where this goes'".
Day, the 2015 champion, ran down the final fairway to finish before darkness completely enveloped the course, the result of the earlier near two-hour stoppage that prevented 26 players from completing their round.
Australia's Jason Day is in third place two strokes back of Kisner and Matsuyama at six under on the tournament.
Day one leader Thorbjorn Olesen is two over after playing 15 holes in six over par on Friday.
Lahiri said, "Frankly I played solid but it was only in the second nine that I got going". Last week gave me an unbelievable sense of calm. "He was happy as well obviously, to be able to finish and not have to wake up at 5.30". Stroud, ranked 203rd, resumed in the greenside rough at the par-4 fifth hole, chipped to seven feet and sank the par putt.
Wiesberger missed birdie chances, and then three-putted for bogey on the ninth hole from 50 feet.