Two excellent first-half goals from the Spaniard helped La Roja into a 2-0 lead by half time, before Alvaro Morata completed the scoring 13 minutes from the end.
Spain named an interesting squad when a familiar face from their World Cup and Euros-winning golden era returning. Liechtenstein will likely play with as many defenders in its box as possible, a formula that Spain has sometimes struggled to break down before.
He added: "These are three important points, but not definitive".
Is Spain the best team in worldwide football? He was training so well in Sunday's session but unfortunately in the last play of practice, he felt something.
Real Madrid winger Asensio, 21, and Torino striker Belotti, 23, were absent when Italy knocked Spain out of Euro 2016 previous year but have since blossomed into two of the most exciting attacking players in Europe.
Isco lit up the Bernabeu as Spain all but secured their passage to the 2018 World Cup with an impressive 3-0 win over Italy.
The Italians have successfully completed the change of generations and managed to win plenty of games during this hard transition.
Both teams are on 16 points from six matches and it is Spain who is leading courtesy of the goal difference.
"We believe and hope to go to the World Cup", Buffon told TMW Radio. But there's a lingering feeling of unfinished business as far as Italy go, meaning that Julen Lopetegui's side will be keen to put down a marker when the sides do battle at the Bernabéu on Saturday evening. "We can all enjoy him and thank God that he's Spanish". The Italian midfield offered no answer to Spain's incisive play either. The victor of this match is nearly certain to win the group and will be able to rest key players in the final rounds. This is the kind of display we can should expect from them next summer.
Yet, that generation seemed to have had its time when Italy outclassed and outfought a jaded Spain just 15 months ago in Vicente del Bosque's final game in charge at Euro 2016.
The 2010 world champions are three points clear of the Azzurri with three matches remaining and can take another major step toward securing a place in the finals in Russian Federation by beating Liechtenstein away on Tuesday.